SIK2/3-IN-3 (Example 15) is a potent, selective SIK2/3 inhibitor that exhibits preferential inhibitory activity against SIK2 ( IC 50 = 10.3 nM) and SIK3 ( IC 50 = 0.8 nM) over SIK1 ( IC 50 = 801 nM). SIK2/3-IN-3 can be used for the study of inflammatory diseases.
Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > Salt-inducible Kinase (SIK)
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