DNMT1 Degrader-1

Overview

DNMT1 Degrader-1 is a selective DNMT1 degrader with an IC 50 of 202.87 nM and a Kd value of 122 nM. As a molecular glue, DNMT1 Degrader-1 forms a ternary complex with DNMT1 and UHRF1 , thereby triggering UHRF1 -mediated ubiquitination and degradation of DNMT1 , and inhibiting the enzymatic activity of DNMT1 . DNMT1 Degrader-1 inhibits the proliferation of primary acute myeloid leukemia cells and exerts anti-tumor activity. DNMT1 Degrader-1 can be used for the research of acute myeloid leukemia.

Application

Products | Products > Disease Areas > Acute Myeloid Leukemia | Products > Disease Areas > Cancer | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Leukemia/Lymphoma/Myeloma | Products > Disease Areas > Blood Disease | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Epigenetics | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Molecular Glues | Products > Signaling Pathways > DNA Methyltransferase

Product Information

• Catalog No.: HY-182956
• CAS No.: 2962943-72-0
• Molecular Formula: C24H32N4O2
• Molecular Weight: 408.54
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source