GRK2 modulator 1

Overview

GRK2 modulator 1 is an orally active, brain-penetrant and selective GRK2 modulator. GRK2 modulator 1 enhances the active, non-phosphorylated GRK2 and prevents mitochondrial GRK2 and TOMM6 aggregation. GRK2 modulator 1 enhances the non-amyloidogenic processing of APP and prevent PHF-tau , neurodegeneration, and neuronal loss. GRK2 modulator 1 decreases the senescence marker, UPAR , reduces the Alzheimer disease (AD)-related mortality, and prolongs survival. GRK2 modulator 1 exerts neuroprotection by inhibiting HDAC6 , and counteracts age-related cardiac dysfunction. GRK2 modulator 1 can be used for research on AD.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Neurodegenerative Disease | Products > Disease Areas > Alzheimer's Disease | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > G Protein-coupled Receptor Kinase (GRK) | Products > Signaling Pathways > HDAC

Product Information

• Catalog No.: HY-183057
• CAS No.: 2234900-83-3
• Molecular Formula: C21H17NO5
• Molecular Weight: 363.36
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source