AW00718 is a Brachyspira pilosicoli glutamate racemase ( Bp-MurI ) inhibitor. AW00718 binds to Bp-MurI active site residues, forming stable hydrogen bonds and interactions with conserved amino acids in the enzyme’s binding cavity. AW00718 exerts antibacterial and bactericidal activity against Brachyspira pilosicoli in vitro . AW00718 can be used for the research of intestinal spirochaetosis.
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