Scopadulciol

Overview

Scopadulciol is an orally effective β-catenin degrader, HSV-TK activator and proton pump inhibitor . By inducing β-catenin degradation, Scopadulciol downregulates the expression of downstream target genes such as cyclin D1 , c-myc , and survivin ; it also upregulates DR4/DR5 and downregulates Bcl-2 , thereby exerting cytotoxicity and inducing apoptosis in cancer cells. Scopadulciol enhances the tumor-killing and bystander effects of prodrugs via activating HSV-TK , and can inactivate HSV-1 . It shows synergistic antiviral effects when combined with Acyclovir ( HY-17422 ) or Ganciclovir ( HY-13637 ), with no cytotoxicity as a single agent. Scopadulciol can be applied in research related to bladder cancer , cervical cancer , glioblastoma, and digestive system cancers.

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Urogenital Disease | Products > Disease Areas > CNS Neoplasm | Products > Disease Areas > Glioma | Products > Disease Areas > Cervical Cancer | Products > Disease Areas > Urogenital Cancer | Products > Disease Areas > Bladder Cancer | Products > Disease Areas > Digestive System Cancer | Products > Disease Areas > Glioblastoma | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Anti-infection | Products > Research Areas > Neurological Disease | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Stem Cells | Products > Research Areas > Cancer > Cancer Drug Resistance | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Bcl-2 Family | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > HSV | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > β-catenin | Products > Signaling Pathways > c-Myc | Products > Signaling Pathways > Survivin

Product Information

• Catalog No.: HY-183390
• CAS No.: 136565-26-9
• Molecular Formula: C27H36O4
• Molecular Weight: 424.57
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source