NVP-BHS345

Overview

NVP-BHS345 is an ATP-competitive TORC1 / TORC2 inhibitor with an IC 50 of 1 μM for both targets in yeast. NVP-BHS345 acutely inhibits TORC1 / TORC2 kinase activity, even in genetically engineered TOR1 M2282T Saccharomyces cerevisiae strains. NVP-BHS345 also reduces the phosphorylation levels of Ser-232/Ser-233 sites in Sch9 , Ypk1/Ypk2 and Rps6 , and induces hyperphosphorylation of Slt2 and activation of the cell wall integrity pathway. NVP-BHS345 causes depolarization of the actin cytoskeleton , blocks fluid-phase endocytosis, prevents the accumulation of vacuolar lipophilic dyes, and regulates the phosphorylation levels of Ent1 , Pan1 , Prk1 , Akl1 and other cellular proteins.

Application

Products | Products > Disease Areas > Others | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Research Areas > Others | Products > Signaling Pathways > mTOR

Product Information

• Catalog No.: HY-183393
• CAS No.: 1798292-13-3
• Molecular Formula: C25H20N6O
• Molecular Weight: 420.47
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source