Wy 27127

Overview

Wy 27127 is a potent and selective α 2 -adrenergic receptor antagonist. Wy 27127 competitively blocks α 2 -adrenergic receptors, interrupts the negative feedback loop of sympathetic nerve endings, enhances stimulus-evoked norepinephrine release, and blocks agonist-induced inhibition of vas deferens contraction. Wy 27127 shows weak antagonistic effects on α 1 receptors, and exhibits no significant antagonistic activity against 5-hydroxytryptamine, muscarinic, presynaptic dopamine, histamine or β 1 -adrenergic receptors in vitro. Wy 27127 blocks saphenous vein contraction mediated by postsynaptic α 2 -adrenergic receptor agonists. Wy 27127 is applicable to studies related to sympathetic neurotransmission and vascular adrenergic responses.

Application

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Product Information

• Catalog No.: HY-183399
• CAS No.: 95669-35-5
• Molecular Formula: C17H27N3O4S2
• Molecular Weight: 401.54
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source