AX-7396 (RGB-315389) is a pUL97 protein kinase inhibitor with an IC 50 of 0.35 μM against HCMV pUL97 kinase. AX-7396 inhibits the replication of wild-type and agent-resistant HCMV , GPCMV , MCMV and RCMV in vitro, with the strongest potency against MCMV ( IC 50 1.6 μM). AX-7396 shows no significant antiviral activity in a mouse cytomegalovirus infection model. AX-7396 can be used in studies related to cytomegalovirus infection .
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