ETMTC

Overview

ETMTC is an orally active anti-inflammatory and antioxidant agent. ETMTC inhibits IKK-mediated phosphorylation and degradation of IkBα , blocks nuclear translocation and activation of NF-κB , and reduces the expression of ICAM-1 , VCAM-1 , E-selectin , Th2 cytokines and eosinophil chemokines. ETMTC abrogates neutrophil adhesion to endothelial monolayers and inhibits TNF-α-induced ROS production. ETMTC activates Nrf2 , and enhances the activities of mitochondrial complex I and IV. ETMTC reduces lipid peroxidation levels, oxidative DNA damage, cytochrome c and caspase 9 activity, and decreases goblet cell metaplasia and subepithelial fibrosis. ETMTC can be used for the research of inflammatory diseases and asthma.

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Allergy | Products > Disease Areas > Allergic Asthma | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > Reactive Oxygen Species (ROS) | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Keap1-Nrf2 | Products > Signaling Pathways > Caspase | Products > Signaling Pathways > Heme Oxygenase (HO)

Product Information

• Catalog No.: HY-183448
• CAS No.: 117666-86-1
• Molecular Formula: C14H18O4S
• Molecular Weight: 282.36
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source