GBR 13098

Overview

GBR 13098 is a dopamine transporter inhibitor with a rat IC 50 of 43 nM, and exhibits dopaminergic activity in vivo .GBR 13098 selectively blocks dopamine uptake, increasing synaptic dopamine availability, with weaker activity against norepinephrine uptake.GBR 13098 induces ipsilateral circling in lesioned rats and increases locomotor activity in naive mice and habituated rats, with effects attenuated by dopamine receptor antagonism.GBR 13098 reduces DOPA formation in dopamine-rich brain regions and enhances inhibitory responses of substantia nigra zona compacta dopamine neurons to dopamine.GBR 13098 serves as a tool for studying dopaminergic systems.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > Dopamine Transporter

Product Information

• Catalog No.: HY-183482
• CAS No.: 77862-94-3
• Molecular Formula: C30H39F3N2O7S2
• Molecular Weight: 660.77
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source