OKY-1581

Overview

OKY-1581 is a potent, orally active and selective thromboxane A 2 synthase inhibitor. OKY-1581 inhibits TXA 2 synthesis and reduces the generation of its stable metabolite TXB 2 . OKY-1581 shifts arachidonic acid (MCE HY-109590) metabolism toward the production of prostaglandin E, prostaglandin F and 6-keto-prostaglandin F 1α . OKY-1581 modulates the TXA 2 / PGI 2 -related eicosanoid balance and inhibits arachidonic acid-induced platelet aggregation without directly inhibiting the cyclooxygenase step. At high oral doses, OKY-1581 also enhances hepatic peroxisomal β-oxidation and reduces serum triglyceride and cholesterol levels. OKY-1581 attenuates cerebral vasospasm after experimental subarachnoid hemorrhage by reducing TXA 2 -related vasoconstrictive signaling. OKY-1581 can be used in studies of atherosclerosis, cerebral vasospasm after subarachnoid hemorrhage and cardiovascular diseases.

Application

Products | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Cardiovascular Disease | Products > Disease Areas > Atherosclerosis | Products > Signaling Pathways > GPCR/G Protein | Products > Research Areas > Cardiovascular Disease | Products > Signaling Pathways > Prostaglandin Receptor

Product Information

• Catalog No.: HY-183483
• CAS No.: 75987-18-7
• Molecular Formula: C16H14NNaO2
• Molecular Weight: 275.28
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source