A-75943

Overview

A-75943 is a bone resorption inhibitor isolated from Streptomyces sp. SANK 61296, with protein synthesis toxicity . A-75943 inhibits bone resorption in vitro, and also suppresses the increase in serum calcium levels and the decrease in bone mineral density in thyroparathyroidectomized rats. A-75943 inhibits protein synthesis. High concentrations of A-75943 reduce the survival rate of osteoclasts on bone slices, while low concentrations have no effect on the survival rate or morphology of osteoclasts. A-75943 can be used for the research of osteoporosis and hypercalcemia.

Application

Products | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Musculoskeletal and Skin Disease | Products > Disease Areas > Blood Disease | Products > Signaling Pathways > Anti-infection | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Cardiovascular Disease | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > Antibiotic | Products > Signaling Pathways > Endogenous Metabolite

Product Information

• Catalog No.: HY-183495
• CAS No.: 201215-10-3
• Molecular Formula: C15H23NO4
• Molecular Weight: 281.35
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source