ICRF 192

Overview

ICRF 192 is a weak DNA topoisomerase II ( DNA topoisomerase II ) inhibitor with an IC 50 of 91 μM. ICRF 192 forms an iron-chelating derivative via ring-opening hydrolysis, which can displace Fe 3+ from the Fe 3+ -doxorubicin complex. ICRF 192 is used for studies on the structure-activity relationship of bisdioxopiperazines and the cardiotoxicity of anthracycline drugs.

Application

Products | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Cardiovascular Disease | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Cardiovascular Disease | Products > Signaling Pathways > Topoisomerase

Product Information

• Catalog No.: HY-183524
• CAS No.: 58893-33-7
• Molecular Formula: C12H18N4O4
• Molecular Weight: 282.30
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source