O-GlcNAcase-IN-6 is an orally active, blood-brain barrier-permeable O-GlcNAcase ( OGA ) inhibitor with an IC 50 of 5.4 nM. O-GlcNAcase-IN-6 inhibits OGA activity, thereby increasing the level of O-GlcNAc glycosylation in brain tissues. O-GlcNAcase-IN-6 can be used for the research of Alzheimer's disease.
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