L-His-BPA

Overview

L-His-BPA is a prodrug of L-p-Boronophenylalanine (L-BPA) ( HY-W087830 ), formed by the peptide bond linkage of L-histidine (L-His) ( HY-N0832 ) and L-BPA. L-His-BPA is rapidly cleaved by endogenous proteases to de novo release L-BPA in the systemic circulation. When used in combination with neutron irradiation, L-His-BPA induces complete and durable tumor regression, elicits cancer vaccine responses, and produces abscopal inhibitory effects on unirradiated distant tumors. L-His-BPA can be used in studies of boron neutron capture therapy (BNCT) for relapsed/advanced solid tumors.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Others | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Drug Intermediate

Product Information

• Catalog No.: HY-183596
• CAS No.: 2941355-21-9
• Molecular Formula: C15H19BN4O5
• Molecular Weight: 346.15
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source