15-PGDH-IN-5

Overview

15-PGDH-IN-5 (compound 5) is a sulfoxide-derived 15-PGDH inhibitor. 15-PGDH-IN-5 exhibits higher metabolic stability and superior in vivo exposure compared with the lead compound SW033291 ( HY-16968 ). 15-PGDH-IN-5 inhibits the irreversible oxidative catabolism of PGE2 by 15-PGDH , thereby enhancing the tissue-specific bioavailability of endogenous PGE2. 15-PGDH-IN-5 exerts anti-inflammatory effects and accelerates tissue repair and regeneration, and it is used in studies on tissue injury and fibrosis-related diseases such as inflammatory bowel disease and idiopathic pulmonary fibrosis.

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Respiratory Disease | Products > Disease Areas > Pathogens Infection | Products > Disease Areas > Pulmonary Disease | Products > Disease Areas > Gastroenteritis | Products > Disease Areas > Lung Fibrosis | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > 15-PGDH

Product Information

• Catalog No.: HY-183651
• CAS No.: 1714984-32-3
• Molecular Formula: C19H21N5OS3
• Molecular Weight: 431.60
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source