MEK-IN-10

Overview

MEK-IN-10 is an orally active pan- MEK / RAF non-degrading molecular glue with an IC 50 of 782 nM against human MEK1 . MEK-IN-10 blocks the phosphorylation of MEK and ERK , induces and stabilizes the MEK1 - RAF complex, and disrupts the RAS - MAPK signaling pathway. MEK-IN-10 induces apoptosis in cancer cells and arrests cells at the G0/G1 phase. MEK-IN-10 induces tumor growth inhibition in mouse xenograft models. MEK-IN-10 can be used in the research of RAS-driven cancers, such as colorectal cancer and pancreatic cancer .

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Colorectal Cancer | Products > Disease Areas > Digestive System Cancer | Products > Disease Areas > Pancreatic Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > PERK | Products > Signaling Pathways > Ras | Products > Signaling Pathways > p38 MAPK | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Molecular Glues | Products > Signaling Pathways > MEK | Products > Signaling Pathways > Raf

Product Information

• Catalog No.: HY-183674
• CAS No.: 3096958-11-8
• Molecular Formula: C22H21ClFN5O5S
• Molecular Weight: 521.95
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source