FXR agonist 18

Overview

FXR agonist 18 is an orally active FXR agonist, with an EC 50 of 10 nM against human FXR and an EC 50 of 1360 nM against human TGR5 . FXR agonist 18 inhibits inflammatory responses by reducing nitrite production, downregulating the expression of pro-inflammatory genes ( Tnf , Adgre1 , Cyp8b1 , upregulating the expression of FXR , Hmox1 , Nqo1 , Nrf2 , and enhancing antioxidant responses. FXR agonist 18 ameliorates liver fibrosis in mice, exhibits protective effects in mice with cholestatic liver injury, and shows anti-MASH efficacy. FXR agonist 18 can be used in studies of metabolic dysfunction-associated steatohepatitis.

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Digestive System Inflammation | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > NF-κB | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Cardiovascular Disease | Products > Signaling Pathways > Quinone Reductase | Products > Signaling Pathways > Keap1-Nrf2 | Products > Signaling Pathways > FXR | Products > Signaling Pathways > G protein-coupled Bile Acid Receptor 1 | Products > Signaling Pathways > TNF Receptor | Products > Signaling Pathways > Heme Oxygenase (HO)

Product Information

• Catalog No.: HY-183692
• CAS No.: 3061938-00-6
• Molecular Formula: C27H44N2O3S
• Molecular Weight: 476.71
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source