Antiviral agent 85 is a broad-spectrum arenavirus entry inhibitor with an EC 90 of 0.13 µM against Junín virus ( JUNV ). Antiviral agent 85 blocks the entry of various arenaviruses through both hTfR1 -dependent and hTfR1 -independent pathways, acting on the early and early post-entry stages of infection . Antiviral agent 85 exhibits antiviral activity against a variety of arenaviruses, is well tolerated in hTfR1-expressing JUNV-infected mouse models, but fails to provide protective effects. Antiviral agent 85 can be used in studies related to arenavirus hemorrhagic fevers.
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