RORγt inverse agonist 37

Overview

RORγt inverse agonist 37 is an orally active RORγt inverse agonist with an IC 50 of 10.8 nM against human targets. RORγt inverse agonist 37 destabilizes helix 12 of RORγt in the agonist-bound conformation, thereby inhibiting transcriptional activity. RORγt inverse agonist 37 inhibits the secretion of IL-17 in cells and in LPS-induced systemic inflammation mouse models. RORγt inverse agonist 37 improves disease-related symptoms in mouse models of psoriasiform dermatitis. RORγt inverse agonist 37 can be used in research related to psoriasiform dermatitis and systemic inflammation.

Application

Products | Products > Disease Areas > Psoriasis | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Autoimmune Disease | Products > Disease Areas > Skin Inflammation | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Vitamin D Related/Nuclear Receptor | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > ROR | Products > Signaling Pathways > Interleukin Related

Product Information

• Catalog No.: HY-183763
• CAS No.: 3134806-34-8
• Molecular Formula: C31H33F5N2O5S
• Molecular Weight: 640.66
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source