ZSW

Overview

ZSW is a hexokinase 2 ( HK2 ) inhibitor with human HK2 IC 50 of 0.48 μM, human HK2 K a of 252.00 μM, and selectivity over HK3 and GCK . ZSW binds directly to HK2 , inhibits its enzymatic activity, modulates macrophage phenotypes through glycolysis inhibition, and inhibits NF-κB nuclear translocation by preventing IκBα phosphorylation and degradation. ZSW alleviates inflammatory bowel disease (IBD) and improves the intestinal inflammatory state of IBD mice. ZSW can be used for the research of inflammatory bowel disease.

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > Hexokinase

Product Information

• Catalog No.: HY-183809
• CAS No.: 3124329-46-7
• Molecular Formula: C26H22N4O6S
• Molecular Weight: 518.54
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source