F1414-1444

Overview

F1414-1444 is a DBPI skeleton derivative and a potent inhibitor of IspQ (Rv0338c)-targeting Mycobacterium tuberculosis . F1414-1444 binds to the membrane-bound iron-sulfur oxidoreductase IspQ, induces oxidative stress and thiol stress in bacterial cells, upregulates the expression of stress-related genes such as the SigK regulon, thereby inhibiting bacterial proliferation and exerting bactericidal activity. F1414-1444 only inhibits the Mycobacterium tuberculosis complex and Mycobacterium marinum . F1414-1444 can be used in studies related to Mycobacterium tuberculosis .

Application

Products | Products > Disease Areas > Infection | Products > Disease Areas > Bacterial Infection | Products > Disease Areas > Mycobacterium Tuberculosis Infection | Products > Signaling Pathways > Others | Products > Signaling Pathways > Anti-infection | Products > Research Areas > Infection | Products > Signaling Pathways > Drug Derivative | Products > Signaling Pathways > Bacterial

Product Information

• Catalog No.: HY-183865
• CAS No.: 794552-29-7
• Molecular Formula: C21H17NO4
• Molecular Weight: 347.36
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source