SYK-IN-14

Overview

SYK-IN-14 is an orally active Syk and ZAP-70 inhibitor with human Syk IC 50 of 0.006 μM, human ZAP-70 IC 50 of 0.23 μM. SYK-IN-14 functionally inhibits Syk kinase activity in vitro . SYK-IN-14 functionally inhibits ZAP-70 kinase activity in vitro . SYK-IN-14 suppresses passive cutaneous anaphylaxis reaction in Mus musculus mice. SYK-IN-14 suppresses Concanavalin A ( HY-P2149 )-induced IL-2 production in Mus musculus mice. SYK-IN-14 can be used for the research of allergic disorders and autoimmune diseases.

Application

Products | Products > Disease Areas > Allergy | Products > Disease Areas > Experimental Autoimmune Encephalomyelitis | Products > Disease Areas > Experimental Autoimmune Encephalomyelitis | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Autoimmune Disease | Products > Disease Areas > CNS Infection | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > Syk | Products > Signaling Pathways > Tyrosinase

Product Information

• Catalog No.: HY-183924
• CAS No.: 725237-11-6
• Molecular Formula: C21H27N7O3
• Molecular Weight: 425.48
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source