IDO1/TDO-IN-12

Overview

IDO1/TDO-IN-12 is an IDO1 / TDO2 inhibitor with IC 50 values of 0.825 and 4.04 μM, respectively. IDO1/TDO-IN-12 interacts with the ferrous heme cofactor in IDO1 as a non-competitive tryptophan inhibitor. IDO1/TDO-IN-12 inhibits nitric oxide production in LPS ( HY-D1056 )-stimulated immune cells. IDO1/TDO-IN-12 relieves pulmonary edema and lung injury in LPS-induced mouse models. IDO1/TDO-IN-12 can be used for the research of acute lung injury (ALI).

Application

Products | Products > Disease Areas > Pulmonary Disease | Products > Disease Areas > Respiratory Inflammation | Products > Disease Areas > Acute Lung Injury | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Respiratory Disease | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > Indoleamine 2,3-Dioxygenase (IDO) | Products > Signaling Pathways > TNF Receptor | Products > Signaling Pathways > Interleukin Related

Product Information

• Catalog No.: HY-184027
• CAS No.: 2841468-09-3
• Molecular Formula: C19H17ClF3N3O5S2
• Molecular Weight: 523.93
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source