ZL006-05

Overview

ZL006-05 is an orally active, brain-penetrant nNOS–PSD-95 and α2-containing GABA A dual-target inhibitor. ZL006-05 blocks the nNOS-PSD-95 protein-protein interaction and selectively potentiatesα2-containing GABA A receptors. ZL006-05 attenuates central sensitization and strengthens inhibitory GABAergic synaptic transmission. ZL006-05 can be used for the study of neuropathic pain, cancer pain, chemotherapy-induced peripheral neuropathic pain, ischemic stroke, poststroke depression and anxiety.

Application

Products | Products > Disease Areas > Anxiety or Fear-Related Disease | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Depression | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Signaling Pathways > Neuronal Signaling | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > iGluR | Products > Signaling Pathways > GABA Receptor | Products > Signaling Pathways > NO Synthase

Product Information

• Catalog No.: HY-184108
• CAS No.: 2486316-20-3
• Molecular Formula: C24H27Cl2NO4
• Molecular Weight: 464.38
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source