(R)-pMeO-Bz-SF, the R isomer of pMeO-Bz-SF ( HY-184117 ), is an α-chymotrypsin inhibitor with an IC 50 of 101 nM. (R)-pMeO-Bz-SF covalently modifies Ser195, Ser190, and Tyr146 in or near α-chymotrypsin’s hydrophobic S1 binding pocket. (R)-pMeO-Bz-SF inhibits α-chymotrypsin in a stereoselective manner.
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