KGDI-109 is an orally active and selective Porphyromonas gingivalis dipeptidyl peptidase 7 ( PgDPP7 ) inhibitor with an IC 50 of 53.8 µM and a K i of 25.1 µM. KGDI-109 is also a selective antibacterial agent that suppresses Porphyromonas gingivalis growth, reduces oral Porphyromonas gingivalis levels, and suppresses alveolar bone resorption. KGDI-109 preserves gut microbial diversity. KGDI-109 can be used for the research of periodontitis.
Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Anti-infection | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > Dipeptidyl Peptidase | Products > Signaling Pathways > Bacterial
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