AAP-SO2

Overview

AAP-SO2 is a Bactericide and Mycobacterium tuberculosis RNA polymerase ( Mtb RNAP ) inhibitor, with an IC 50 of 0.025 μM against Mtb RNAP. AAP-SO2 allosterically slows the nucleotide addition rate during transcriptional elongation and enhances transcription termination efficiency. AAP-SO2 exhibits increased activity against β S450L -type Mtb, possesses activity against non-replicating Mtb, and shows whole-cell activity against Mtb and related mycobacterial species. AAP-SO2 reduces the overall emergence rate of Rifampicin ( HY-B0272 ) tolerance in Mtb, alters the mutation spectrum, and decreases the proportion of β S450L -type Rifampicin -resistant mutants. AAP-SO2 acts synergistically with Rifampicin to kill non-replicating Mtb in a rabbit caseous necrosis model. AAP-SO2 can be used for the research of tuberculosis.

Application

Products | Products > Disease Areas > Infection | Products > Disease Areas > Bacterial Infection | Products > Disease Areas > Mycobacterium Tuberculosis Infection | Products > Signaling Pathways > Anti-infection | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Infection | Products > Signaling Pathways > Bacterial | Products > Signaling Pathways > DNA/RNA Synthesis

Product Information

• Catalog No.: HY-184408
• CAS No.: 3033990-94-9
• Molecular Formula: C26H26FN3O4S
• Molecular Weight: 495.57
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source