(R,R,R)-AHPC is an E3 ubiquitin ligase ligand and serves as one of the E3 ligands for R4VPL3-1 ( HY-184506 ). R4VPL3-1 is a molecular glue targeting RNF4 and VHL, which binds to and modifies GPX4 to inhibit its anti-ferroptosis function. R4VPL3-1 induces iron-dependent lipid peroxidation and ferroptosis-mediated rapid cell death in cancer cells. R4VPL3-1 can be used for cancer-related research.
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