YS-01

Overview

YS-01 is an inhibitor of pendrin (SLC26A4) with pulmonary protective activity. YS-01 inhibits pendrin-mediated anion exchange activity, reduces pendrin expression, and suppresses the activation of NF-κB and the production of proinflammatory cytokines. YS-01 alleviates lipopolysaccharide-induced and ventilator-induced lung injury. YS-01 attenuates ovalbumin-induced airway hyperresponsiveness, inflammatory infiltration, epithelial thickening and goblet cell hyperplasia, and reduces eosinophil and neutrophil counts. YS-01 decreases MUC5AC transcription levels induced by IL-4 , reverses the reduction of airway surface liquid volume, and inhibits the increase of apical SCN − concentration in epithelial cells. YS-01 can be used in studies related to lung injury and allergic asthma.

Application

Products | Products > Disease Areas > Respiratory Inflammation | Products > Disease Areas > Allergic Asthma | Products > Disease Areas > Acute Lung Injury | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Respiratory Disease | Products > Disease Areas > Allergy | Products > Disease Areas > Pulmonary Disease | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Signaling Pathways > NF-κB | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > Chloride Channel | Products > Signaling Pathways > NF-κB

Product Information

• Catalog No.: HY-184897
• CAS No.: 312724-83-7
• Molecular Formula: C18H17NO2S
• Molecular Weight: 311.40
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source