PDSinh-C01 is a reversible, non-competitive pendrin (SLC26A4) inhibitor with an IC 50 of 2.5 μM. PDSinh-C01 inhibits pendrin -mediated Cl − /SCN − exchange activity, reduces cell counts, protein levels, and pro-inflammatory cytokine production in bronchoalveolar lavage fluid. PDSinh-C01 can be used in research related to acute lung injury and cystic fibrosis.
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