LMP2-IN-1

Overview

LMP2-IN-1 is an orally bioavailable, brain-permeable macrocyclic peptide epoxyketone, acts as a selective and irreversible inhibitor of LMP2 ( IC 50 = 87 nM). LMP2-IN-1 rapidly distributes to the brain and forms an irreversible LMP2:AR-01 adduct. LMP2-IN-1 improves memory function and rescues reactive astrocytes in 5xFAD mouse models of Alzheimer's disease (AD).

Application

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Product Information

• Catalog No.: HY-184919
• CAS No.: 3056058-96-6
• Molecular Formula: C23H36FN3O6
• Molecular Weight: 469.55
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source