PROTAC NSD2 degrader-1

Overview

PROTAC NSD2 degrader-1 is a PROTAC degrader that selectively targets NSD2 , with a DC 50 of 0.37 μM. PROTAC NSD2 degrader-1 induces selective degradation of long and short isoforms of NSD2 containing the PWWP1 domain by forming a ternary complex with FBXO22. NSD2 degradation mediated by PROTAC NSD2 degrader-1 depends on the ubiquitin-proteasome system and the neddylation pathway. PROTAC NSD2 degrader-1 can be used in cancer-related research such as non-small cell lung cancer , multiple myeloma and prostate cancer . (Pink: Target protein ligand; Blue: Ligands for E3 Ligase E3 ligase ligand; Black: linker).

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Epigenetics | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > Histone Methyltransferase

Product Information

• Catalog No.: HY-184968
• CAS No.: 3108071-48-0
• Molecular Formula: C38H34N4O6
• Molecular Weight: 642.70
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source