W19-LNP is a lipid nanoparticle formulated with a Ugi-reaction-derived ionizable lipid (W19). W19-LNP demonstrates highly selective mRNA delivery to the spleen in female BALB/c mice upon intravenous administration. W19-LNP can be used for the research of mRNA-based vaccine delivery, immune cell reprogramming, and gene-engineered cell preparation.
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