HMRef-βGal

Overview

HMRef-βGal is a fluorescent probe and a substrate responsive to β-galactosidase ( β-galactosidase ) ( Ex/Em =498 nm/505-600 nm). After being cleaved by β-galactosidase, HMRef-βGal triggers significant fluorescence enhancement via intramolecular spirocyclic function regulation. HMRef-βGal generates bright fluorescence in cancer cells with elevated β-galactosidase activity, enabling visualization of tiny peritoneal metastases in mouse models. HMRef-βGal exhibits low in vitro cytotoxicity and low acute in vivo toxicity in mice. HMRef-βGal can be used for preclinical fluorescence-guided diagnosis and cytoreductive surgery of peritoneal metastases, including compatibility with real-time naked-eye detection and endoscopic imaging, as well as for studies related to peritoneal metastases of ovarian cancer .

Application

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Product Information

• Catalog No.: HY-D3186
• CAS No.: 2163840-29-5
• Molecular Formula: C28H26F3NO8
• Molecular Weight: 561.50
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source