BODIPY−DOX

Overview

BODIPY-DOX is a conjugate composed of BODIPY and Doxorubicin ( HY-15142A ), as well as a pH-activated fluorescent probe for M1 macrophages and an apoptosis inducer. BODIPY-DOX undergoes pH-induced hydrazone bond cleavage in acidic M1 macrophage phagosomes, thereby releasing cytotoxic Doxorubicin (Dox) and inhibiting the function of pro-inflammatory M1 macrophages. BODIPY-DOX highly selectively inhibits the production of relevant pro-inflammatory cytokines by mouse and human monocyte-derived M1 macrophages, while exerting minimal effects on M2 or unactivated macrophages. Therefore, BODIPY-DOX enables simultaneous fluorescent tracing, differentiation and elimination of specific macrophage subsets, and exhibits the potential to regulate tissue regeneration in zebrafish models.

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > Others | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > Fluorescent Dye | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-D3190
• CAS No.: 2173116-67-9
• Molecular Formula: C54H62BF2N7O12
• Molecular Weight: 1049.92
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source