NIR-ASM is a near-infrared fluorescent probe that can cross cell membranes and be activated by NQO1 . NIR-ASM can distinguish NQO1 -expressing cancer cells from normal cells via fluorescence microscopy and flow cytometry. NIR-ASM generates near-infrared fluorescence with a high signal-to-noise ratio in tumor models with NQO1 activity, enabling the detection of endogenous NQO1 activity in vivo. NIR-ASM is applicable to the research of lung cancer and breast cancer .
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