NIR-PN1 is a blood-brain barrier-permeable near-infrared fluorescent indicator targeting peroxynitrite anion (ONOO − ) (Ex/Em = 510 nm/670 nm). NIR-PN1 reacts with ONOO − to trigger a strong near-infrared fluorescence enhancement, enabling the detection of ONOO − flux. NIR-PN1 allows the imaging of ONOO − flux in various Parkinson's disease models. NIR-PN1 is applicable to Parkinson's disease-related research.
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