Vernodalin

Overview

Vernodalin is an orally active, cytotoxic sesquiterpene lactone with a K d value of 9.55 μM for p38 MAPK . Vernodalin downregulates the expression of phosphorylated ERK , JNK , AKT , PI3K , mTOR , p38MAPK , FAK , MMP-2 , MMP-9 , and uPA , while upregulates the expression of TIMP-1 and TIMP-2 . Vernodalin increases ROS production, upregulates the expression of Bax and caspase 3 , downregulates the expression of Bcl-2 , and induces apoptosis ( apoptosis ), oxidative stress response and cell cycle arrest. Vernodalin inhibits the proliferation, adhesion and metastasis of cancer cells. Vernodalin enhances the activity of VEGF-B , AMPK and eNOS signaling pathways. Vernodalin alleviates myocardial injury and restores hemodynamic parameters. Vernodalin inhibits the growth of Trypanosoma brucei rhodesiense . Vernodalin can be used in research related to various cancers including gastric cancer , colorectal cancer and lung cancer , as well as African human trypanosomiasis and myocardial infarction.

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Infection | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Parasitic Infection | Products > Disease Areas > Heart Disease | Products > Disease Areas > Lung Cancer | Products > Disease Areas > Colorectal Cancer | Products > Disease Areas > Digestive System Cancer | Products > Disease Areas > Gastric Cancer | Products > Disease Areas > Trypanosome Infection | Products > Disease Areas > Myocardial Infarction | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > Anti-infection | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Infection | Products > Research Areas > Cardiovascular Disease | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > p38 MAPK | Products > Signaling Pathways > PERK | Products > Signaling Pathways > JNK | Products > Signaling Pathways > Akt | Products > Signaling Pathways > PI3K | Products > Signaling Pathways > mTOR | Products > Signaling Pathways > FAK | Products > Signaling Pathways > MMP | Products > Signaling Pathways > PAI-1 | Products > Signaling Pathways > Reactive Oxygen Species (ROS) | Products > Signaling Pathways > Caspase | Products > Signaling Pathways > Bcl-2 Family | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > VEGFR | Products > Signaling Pathways > AMPK | Products > Signaling Pathways > Parasite

Product Information

• Catalog No.: HY-N19029
• CAS No.: 21871-10-3
• Molecular Formula: C19H20O7
• Molecular Weight: 360.36
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source