Sitaxsentan sodium (Standard)

Overview

Sitaxsentan (sodium) (Standard) is the analytical standard of Sitaxsentan sodium (IPI 1040 sodium; TBC11251 sodium) ( HY-11103 ). This product is intended for research and analytical applications. Sitaxsentan sodium is a potent, selective and orally active endothelin A receptor (ETA) antagonist with an IC 50 of 1.4 nM and a K i of 0.43 nM. Sitaxsentan sodium exhibits an IC 50 for the ETB receptor of as high as 9800 nM. Sitaxsentan sodium is metabolized by CYP2C9 and CYP3A4 , normalizes shunt-induced endothelial abnormalities, restores BMPR signaling, and suppresses pulmonary vascular remodeling and hemodynamic deterioration. Sitaxsentan sodium can be applied in the research of pulmonary arterial hypertension and portopulmonary hypertension.

Application

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Product Information

• Catalog No.: HY-11103R
• CAS No.: 210421-74-2
• Molecular Formula: C18H14ClN2NaO6S2
• Molecular Weight: 476.89
• Purity: 98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.
• Availability: In-stock

Source

Original product source