Dihydrocitrinone is a polyketide secondary metabolite and the major urinary metabolite of citrinin, which can be isolated from Aspergillus strains derived from the rhizosphere soil of date palms. Dihydrocitrinone exerts independent toxic effects in renal cell cultures and zebrafish embryo models, enhances the toxic effects of Ochratoxin A through additive or synergistic actions, and increases the level of miR-731 in zebrafish embryos when acting in combination with Ochratoxin A.
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