Vescalagin

Overview

Vescalagin is a hexahydroxyphenol. Vescalagin is isolable from Camu-camu ( Myrciaria dubia ) and immature wax apple fruits. Vescalagin exhibits inhibitory activity against a variety of enzymes , with a K i value of 5.87 nM against AChE , 3.89 nM against BChE , 11.75 nM against hCA I , 16.23 nM against hCA II , and 16.08 nM against α-glucosidase . Vescalagin inhibits hCA I, hCA II and α-glucosidase in a non-competitive manner. Vescalagin downregulates JNK / p38 MAPK to protect pancreatic β-cells and improve insulin secretion in methylglyoxal-treated rats. Vescalagin reduces hyperglycemia and hypertriglyceridemia in rats fed a high-fructose diet. Vescalagin possesses anti-inflammatory and antioxidant properties.

Application

Products | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Lipid Metabolism | Products > Disease Areas > Glucose Metabolism | Products > Disease Areas > Hypertriglyceridemia | Products > Signaling Pathways > Neuronal Signaling | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Research Areas > Metabolic Disease | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > Cholinesterase (ChE) | Products > Signaling Pathways > Carbonic Anhydrase | Products > Signaling Pathways > Glycosidase | Products > Signaling Pathways > JNK | Products > Signaling Pathways > p38 MAPK

Product Information

• Catalog No.: HY-N19401
• CAS No.: 36001-47-5
• Molecular Formula: C41H26O26
• Molecular Weight: 934.63
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source