2′,3′-Dihydroxypuberulin is a naturally derived inhibitor of the FcεRI β-chain with FcεRI expression inhibitory activity in mast cells. 2′,3′-Dihydroxypuberulin suppresses the mRNA level of the FcεRI β-chain, blocks the assembly of the FcεRI tetramer, and reduces the cell surface expression level of FcεRI. 2′,3′-Dihydroxypuberulin can be used in studies related to type I allergic diseases.
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