Licocoumarone

Overview

Licocoumarone is an active component derived from licorice. Licocoumarone has an IC 50 of 12.56 μM and a K d of 14.90 μM against human DYRK1A . Licocoumarone inhibits NF-κB activation by blocking IκBα degradation and p65 phosphorylation, interferes with MAPK activation via inhibiting phosphorylation, and downregulates the expression of iNOS . Licocoumarone inhibits LPS-induced expression of IL-1β , IL-6 and IL-10 ; it induces apoptosis of pancreatic cancer cells apoptosis and acts as a neuraminidase inhibitor ( IC 50 = 27.8 μM). Licocoumarone exhibits anti-inflammatory and antimicrobial activities, with antibacterial activity against Listeria and antifungal activity against Candida parapsilosis . Licocoumarone can be used in studies related to immune and inflammatory diseases, pancreatic cancer , and specific bacterial and fungal infections.

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Infection | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Pancreatic Cancer | Products > Disease Areas > Digestive System Cancer | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Signaling Pathways > Anti-infection | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Infection | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > NO Synthase | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > p38 MAPK | Products > Signaling Pathways > Bacterial | Products > Signaling Pathways > Fungal | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > DYRK | Products > Signaling Pathways > Interleukin Related

Product Information

• Catalog No.: HY-N20713
• CAS No.: 118524-14-4
• Molecular Formula: C20H20O5
• Molecular Weight: 340.37
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source