SU015

Overview

SU015 (DOTA-RGDfK dimer) is a Integrin α v β 5 and α v β 3 antagonist. SU015 exhibits comparable affinity for α v β 5 and α v β 3 , with relatively higher potency and specificity compared to other integrins. SU015 inhibits α v β 3 -mediated cell adhesion to fibrinogen, α v β 3 -mediated adhesion of activated platelets to osteopontin , and α v β 5 -mediated cell adhesion to vitronectin . SU015 shows potent inhibitory effects on FGF2-induced angiogenesis in the CAM model. SU015 carries a linker arm available for radioisotope conjugation, and acts as a target-specific radioreagent when labeled with 90 Y (i.e., RP697) or 177 Lu (i.e., RP688). SU015 can be used in studies related to tumor metastasis and tumors.

Application

Products | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Cancer | Products > Disease Areas > Cardiovascular Disease | Products > Signaling Pathways > Cytoskeleton | Products > Signaling Pathways > Antibody-Drug Conjugate/ADC Related | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cardiovascular Disease | Products > Signaling Pathways > Integrin | Products > Signaling Pathways > Radionuclide-Drug Conjugates (RDCs)

Product Information

• Catalog No.: HY-P3335
• CAS No.: 250612-06-7
• Molecular Formula: C75H113N23O23
• Molecular Weight: 1704.84
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source