Protein kinase inhibitor 8 (Compound CK59) is a calmodulin-dependent protein kinase II ( CaMKII ) inhibitor. By inhibiting the activity of CaMKII , Protein kinase inhibitor 8 can attenuate the cytotoxicity induced by perfluorooctane sulfonic acid (PFOS) and alleviate the downregulation of GLT-1 expression caused by PFOS, thereby reducing neuronal damage. Protein kinase inhibitor 8 may be useful in research related to neurodegenerative diseases.
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