CE-103

Overview

CE-103 is a selective, blood-brain barrier-permeable dopamine transporter ( DAT ) inhibitor with an IC 50 of 14.73 μM. CE-103 blocks DAT-mediated dopamine reuptake and exhibits antagonistic activity against 5-HT1A . CE-103 reduces working memory errors in the radial arm maze test of rats, decreases the levels of complexes containing phosphorylated DAT (pDAT) and D1R in the hippocampus of rats, and increases the levels of complexes containing D2R and D3R simultaneously. CE-103 can be used in studies related to dopaminergic neurotransmission, working memory and cognitive function.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Cerebrovascular Disease | Products > Signaling Pathways > Neuronal Signaling | Products > Signaling Pathways > GPCR/G Protein | Products > Research Areas > Cardiovascular Disease | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > Dopamine Transporter | Products > Signaling Pathways > 5-HT Receptor

Product Information

• Catalog No.: HY-W1133231
• CAS No.: 1879038-73-9
• Molecular Formula: C17H15NOS2
• Molecular Weight: 313.44
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source