LY164846 is an orally active cephalosporin. LY164846 is highly sensitive to Haemophilus influenzae (including Ampicillin ( HY-B0522 )-resistant strains) and Moraxella catarrhalis (with MIC 90 ≤ 4 μg/mL). LY164846 is generally sensitive to Methicillin ( HY-121544 )-resistant Staphylococcus aureus and Streptococcus (except Enterococcus ) (with MIC 90 : 0.25 - 8 μg/mL), and moderately sensitive to anaerobic bacteria. LY164846 has MBC/MIC ratio to Haemophilus influenzae of ≤ 2, showing bactericidal activity. LY164846 can be used for research on respiratory and skin infections.
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