1,6-Dimethoxyhexane

Overview

1,6-Dimethoxyhexane is an aliphatic ether that serves as a PROTAC linker and fuel additive. 1,6-Dimethoxyhexane is an orally active testicular toxicant. It has no direct toxicity on its own, but exerts toxicity after oxidative metabolism by liver/testicular microsomes to produce 2-Methoxyacetic Acid (MAA). 1,6-Dimethoxyhexane induces apoptosis /necrosis of pachytene spermatocytes, downregulates the expression of HSP70 .2 , HSP60 and ERp60/PDI A3 , and causes spermatogenic tubule degeneration, testicular/thymic atrophy, a sharp decline in epididymal sperm density, and other effects. 1,6-Dimethoxyhexane can be used in studies related to testicular toxicity.

Application

Products | Products > Disease Areas > Male Reproductive System Disease | Products > Disease Areas > Urogenital Disease | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Endocrinology | Products > Signaling Pathways > PROTAC Linkers | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > HSP

Product Information

• Catalog No.: HY-W275882
• CAS No.: 13179-98-1
• Molecular Formula: C8H18O2
• Molecular Weight: 146.23
• Storage: Store at room temperature 3 years. In solvent -80°C, 2 years , -20°C, 1 year
• Availability: In-stock

Source

Original product source