Pirlindole (Pyrazidole; Pirazidole) hydrochloride is an orally active, selective, reversible, blood-brain barrier-permeable MAO-A inhibitor with weak inhibitory effects on norepinephrine transporters and serotonin transporters . Pirlindole hydrochloride secondarily inhibits the reuptake of norepinephrine and serotonin to elevate central neurotransmitter levels, thereby producing antidepressant effects, and also exhibits multiple activities including anticonvulsant, analgesic, local anesthetic, blood pressure-regulating, and platelet aggregation-inhibiting properties. Pirlindole hydrochloride is widely applicable to research on major depressive disorder and related depressive conditions.
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